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Z-DNA

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Z-DNA is a form of DNA in which the double helix winds to the left in a zig-zag pattern (instead of to the right, like the more common B-DNA form).

Z-DNA was discovered in 1979 by Alexander Rich and colleagues at MIT.

A algorithm for predicting the propensity of B-DNA to flip into Z-DNA, ZHunt, was written by Dr. P. Shing Ho in 1984. This algorithm was later developed by Tracy Camp, P. Christoph Champ, Sandor Maurice, and Jeffery M. Vargason for genome-wide mapping of Z-DNA (with P. Shing Ho as the principal investigator).

References

  • P. Christoph Champ, Sandor Maurice, Jeffery M. Vargason, Tracy Camp, and P. Shing Ho. Distributions of Z-DNA and Nuclear Factor I in human chromosome 22: A model for coupled transcriptional regulation. Nucleic Acids Res.

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This page was last modified 04:12, 12 Sep 2004.
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