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Mister Sinister is a fictional character, a supervillain in Marvel Comics' universe. Sinister is a long-lived and scheming foe of the X-Men and X-Factor. He was first mentioned in Uncanny X-Men #212, by the villain Sabretooth, but he did not appear on-panel until issue #222.
Powers & Abilities
Mister Sinister has vaguely-defined powers. He has exhibited vast shape-changing and regenerative abilities, incredible resistance to injury, teleportation, blasts of concussive force, and he has apparently survived having the flesh blasted off his bones at the climax of the Inferno crossover. However, he has also demonstrated telepathic abilities in the past, suggesting that any number of potential uses of his powers may have actually been mentally projected illusions.
Sinister is a geneticist of the highest order, able to predict genetic mutations and splice DNA to create mutants to his whim. He can also produce large amounts of clones; he has done so with his Marauders, and with Jean Grey. He is also a master surgeon, having excised a portion of Gambit's brain, and then later restoring it (or from Sinister's point of view, restoring a portion of Gambit's brain, then excising it).
Unfortunately, Sinister has no conscience, and does not care how many lives are destroyed in pursuit of his ultimate goals; he is known to have collaborated with members of the Nazi party.
History
Mister Sinister was formerly known as Nathaniel Essex, a biologist in Victorian England, who was fascinated with Charles Darwin's concept of natural selection and genetic mutations. His radical theories and experiments, however, received derision from his colleagues in the London Royal Society, and they cut off his work.
Without funding or a proper facility, Essex resorted to experimenting on the dregs of society, using a group of thugs he called Marauders to bring him material to experiment on. The Marauders disturbed the resting place of an ancient evil, the entity known as Apocalypse. When Apocalypse learned of Essex's work, he realized that it explained his existence. Apocalypse convinced Essex to work for him, after being rejected by his contemporaries and his wife, and transformed him into a new breed of being.
At that moment, Nathaniel Essex discarded his old name, and called himself "Sinister." Apocalypse's first command was to create a plague to destroy the weak of the world, but Sinister would not do it; he had clarity of purpose, and cruelty for its own sake was not part of it. The plague Sinister created attacked only Apocalypse, driving him into hibernation.
Sinister's next plan was to use selective breeding to create a mutant that could destroy Apocalypse, and over the course of a hundred years, he found the ideal genetic match between Marvel Girl (Jean Grey) and Cyclops (Scott Summers).
He created Madelyne Pryor, a clone of Grey, and set her up to meet Summers and eventually bear his child. She did, but Sinister's plan hit a snag when Apocalypse infected the child with a techno-organic virus that would soon kill him. The child was taken far into the future, where he became Cable.
The villain Stryfe tricked Sinister into unleashing the Legacy Virus, decimating the mutant population, and let slip to Cyclops that he has more than one brother (the one known brother being Havok). (Speculation abounds as to who that third brother is, though most evidence (and some semi-official statements) indicate Adam-X, the X-Treme, is that brother. It is theorized that Adam-X is the product of the rape of Cyclops' mother by D'Ken, thus making Adam-X the illegitimate heir to the throne of the Shi'ar Empire.)
Fortunately for Sinister, Cable also had a deep grudge against Apocalypse, and when Apocalypse merged with Cyclops at the climax of "The Twelve," Cable and Jean Grey (Phoenix IV) tracked the merged being, separated them, and Cable killed Apocalypse, fulfilling his destiny as written by Sinister.
Sinister continues his research into mutant genetics, and recently reappeared in the pages of the new Weapon X series.
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