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In biology, histones are the chief proteins of chromatin. They act as spools around which DNA winds and they play a role in gene regulation.
Histones are found in the nuclei of eukaryotic cells. Bacteria do not have histones. However, the DNA of the genus Thermoplasma (in the domain Archaea) is surrounded by a highly basic DNA-binding protein which strongly resembles the eukaryotic histones.
Classes
Five histone classes are known:
Two each of class H2A, H2B, H3 and H4 assemble to form one nucleosome, together with DNA. H1 is needed for histone-DNA-complexes to form a 30-nm fiber, which packs the DNA even more tightly.
Functions
Histones act as spools around which DNA winds and they play a role in gene regulation.
Histones act as spools for DNA. This enables the compaction necessary to fit the large genomes of eukaryotes inside cell nuclei.
Histones act in gene regulation. Histones can undergo posttranslational modifications. These modifications can play a role in gene regulation in an epigenetic manner. Regulation occurs at the TATA box.
Structure
The proteins comprising histones are rich in lysine and arginine and are water-soluble.
Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, acetylation, phosphorylation, ubiquitination, and ADP-ribosylation. This effects their function of gene regulation (see functions).
In general, genes that are active have less bound histone, while inactive genes are highly associated with histones during interphase. It also appears that the structure of histones have been evolutionarily conserved.
History
Histones were discovered in 1884 by Albrecht Kossel. The word "histone" dates from the late 19th century and is from the German "Histon", of uncertain origin: perhaps from Greek histanai or from histos.
Until the early 1990s, histones were dismissed as merely packing material for nuclear DNA. During the early 1990s, the regulatory functions of histones were discovered.
See also
ca:histona
de:histon
es:histona
ja:ヒストン
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